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Medically reviewed by Suzanne Fisher, registered dietitian
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Conditions such as liver disease, obesity, or Crohn’s disease increase the risk of vitamin B6 deficiency.
- Vitamin B6 deficiency can cause mental health symptoms, rashes, ulcers, or cracks in the mouth or tongue.
- More serious symptoms of low vitamin B6 levels include anemia, nerve damage, and muscle loss.
- If you think you may be vitamin B6 deficient, contact your health care provider to have your vitamin B6 levels checked.
Vitamin B6, or Pyridoxineproduce antibodies to fight infection, regulate blood sugar, and help your brain and nervous system work efficiently. When vitamin B6 levels are too low, you may develop a deficiency. When you are deficient in vitamin B6, the following may happen to your body.
1. Emotional changes
Low levels of vitamin B6 are associated with symptoms such as confusion, brain fog, irritability, anxiety, and depression.
People who take vitamin B6 supplements may experience less anxiety and depression. This may be because the vitamin supports the nervous system and helps the body regulate stress and tension.
2. Changes in the mouth and tongue
People with very low levels of vitamin B6 may develop mouth ulcers, cheilitis (chapped lips), and dryness around the mouth.
Some people may experience glossitis (inflammation of the tongue) and tongue pain.
3. Rash
Low levels of vitamin B6 can lead to a skin condition called seborrheic dermatitis. Symptoms include a red, scaly, flaky or greasy rash, usually on the back, face or scalp. The skin may also peel (shed) or become irritated.
4. Anemia
Vitamin B6 plays an important role in the production of hemoglobin, a protein in red blood cells that helps provide oxygen to body tissues.
Severe vitamin B6 deficiency can cause a type of anemia called microcytic anemia, which causes red blood cells to be abnormally small.
Symptoms of anemia include fatigue, shortness of breath, difficulty concentrating, weakness, headache, loss of appetite, dizziness, and increased heart rate.
5. Peripheral neuropathy
Because vitamin B6 helps protect nerve function, vitamin B6 deficiency may cause nerve damage if left untreated. One possible result is peripheral neuropathy, which is damage to the nerves in the arms, hands and feet.
People with peripheral neuropathy may experience pins and needles sensations, such as tingling and tingling, in their extremities. They may also experience decreased reflexes, numbness, muscle weakness, and pain.
6. Ataxia
In severe cases, vitamin B6 deficiency can cause Ataxiawhich is a loss of muscle control. Symptoms include balance and coordination problems, clumsiness, difficulty walking, and slurred speech.
Vitamin B6 deficiency symptoms in children
Symptoms of vitamin B6 deficiency may differ in infants and young children.
Common symptoms of vitamin B6 deficiency in infants include:
- Irritability and excessive crying
- Hearing is particularly sensitive and sharp
- epileptic seizure
When to seek care
If you continue to experience any of the above symptoms, contact your healthcare provider. They can perform a physical exam, review your medical history, and test your B6 levels with a serum (blood) test.
You may be at risk for vitamin B6 deficiency if you:
- kidney disease
- Liver disease
- Autoimmune diseases, such as rheumatoid arthritis (RA)
- Digestive disorders that affect your ability to absorb nutrients from food, such as Crohn’s disease
- Alcohol use disorder (AUD)
- obesity
- Other vitamin B deficiencies
Treatment of vitamin B6 deficiency varies from person to person.
Your provider may recommend eating more B6-rich foods, taking vitamin B6 or B-complex supplements, treating any underlying conditions that impair B6 absorption, or a combination of these approaches.
Questions to ask your provider
If you think you may be vitamin B6 deficient, consider asking your healthcare provider the following questions:
- Are there other possible causes for my symptoms?
- Can other medications interact with vitamin B6 supplements?
- How to get more vitamin B6 in your diet?
- What are the possible complications of vitamin B deficiency?
- What are the potential side effects of vitamin B6 supplements?